Debora Barton

Debora Barton

Company: Carisma Therapeutics

Job title: Chief Medical Officer


Debora Barton joined Carisma Therapeutics in November 2019. She brings 18 years of oncology experience, both in academia as a practicing physician and in the biotechnology/pharmaceutical industry. Most recently, she served in key senior executive positions in cellular therapy and radiopharmaceutical biotech companies including Iovance Biotherapeutics and Advanced Accelerator Applications, acquired by Novartis during Debora’s tenure. In her leadership roles, Debora built Clinical Development and Drug Safety teams, setting up infrastructure for the conduct of clinical studies and was instrumental in obtaining FDA Breakthrough Designation for a cell therapy product and in the approval of a radiopharmaceutical agent by both FDA and EMA. Previously, Debora spent 10 years at Celgene and Novartis, always focusing on improving the lives of cancer patients. She holds an MD from Pontificia Universidade Catolica Sao Paulo (PUC-SP) and completed her fellowship in Oncology at Federal University of Sao Paulo (UNIFESP) in Brazil.


Designing & Carrying Out a Successful Basket Trial for a HER2 Agent 2:30 pm

• Site selection, tumor indication selection • Patient recruitment and selection: aligning everyone on the trial testing-wise • Exploring the benefits and drawbacks to basket trials – presenting them to regulators, budgets, implementation, planning, results, potential • Understanding the similarities and differences between tumors in study and why it’s importantRead more

day: Day Two

Closing Panel Discussion: Thoughts & Future Directions for HER2 4:30 pm

• Thoughts and rationalizing on potential best combinations for HER2 targets • Reviewing the various combination approaches and new targets coming in thought experiment based on pathway • Thoughts on biosimilars • Understanding the effects and pathology on downstream signaling when resistance arises – along the development and progress • Understanding the movement towards considering…Read more

day: Day Two

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